UA Anti-Aging Agent

 Source: pomegranate, raspberry

 English chemical name:3,8-dihydroxy-urolithin

 Properties: light yellow or yellow powder

 Detection method: HPLC

 Cas number:1143-70-0

 Molecular formula:C13H8O4

 Molecular weight:228.2

 Purity: HPLC≥98%

 What is Urolithin A

 Urolithin A(UA)is a natural polyphenol compound ellagitannin(ET)intestinal flora metabolite, which was discovered and officially named by Begoña Cerdáin in 2005.

 ETs are metabolic precursors of UA. In the biological world, they are mainly found in natural plants such as pomegranates, strawberries, walnuts, and raspberries.ETs are converted into ellagic acid(EA)in the upper digestive tract, further de-lactone ring and decarboxylation to generate urolithin M5(UM5).UM5 removes hydroxyl groups at different positions and numbers under the catalysis of dehydroxylase to produce a series of urolithin-like substances and finally metabolizes to produce UA. Its chemical structure can be regarded as a benzocoumarin compound with a dibenzopyran-6-one derivative substituted with 2 hydroxyl groups.

 Application prospects of urolithin A

Premise: According to data from the World Health Organization, by 2030, one in every 60 people in the world will reach 60 years old or above. This trend of population aging has created a strong market demand for health and longevity products.

As a compound that can promote the recycling of damaged mitochondria by cells, UA has attracted much attention for its unique health benefits and anti-aging potential. Because of the mature product research and development, it has gradually become an ideal anti-aging supplement choice in the minds of consumers.

In October 2023, urolithin A completed the registration of new cosmetic raw materials in China(registration number is"Guozhuang Yuanbeizi 20230036")and is now in the monitoring period. Its purpose of use is an anti-wrinkle agent and can be used in skin care cosmetics except spray products.

In the United States, UA has passed the FDA's GRAS certification and can be used in foods(such as protein shakes, meal replacement drinks, instant oats, protein and nutrition bars, and yogurt drinks)and dietary supplements.

In Japan, UA is one of the important functional food ingredients. Daicel, Japan, became the first company to successfully achieve commercial production of UA through fermentation technology. In 2021, it launched Urolich®, which is fermented from pomegranate peel.In February of this year,it became the first raw material in Japan to obtain the"Autophagy Label Guidelines"certification,which was formulated by the Japanese Autophagy Alliance.

 UA's efficacy and role

1. Antioxidant effect: It is well known that urolithin A has a strong antioxidant capacity, which can remove free radicals in the body and reduce oxidative damage. Studies have found that UA can bind to peroxisome proliferator-activated receptorγ(PPARγ)and activate the PPARγsignaling pathway, thereby enhancing the antioxidant capacity of cells.

2. Delaying aging: UA has the effect of delaying aging and can prolong life. Studies have found that UA anti-aging agents can inhibit the activity of telomerase and delay cell aging; at the same time, urolithin A can also promote mitochondrial function and improve the energy metabolism level of cells, thereby delaying aging.

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