Spermidine powder

Product Name: Spermidine Trihydrochloride  

CAS No.: 334-50-9  

Molecular Formula: C7H19N3·3HCl  

Molecular Weight: 254.63 g/mol  

Appearance: White crystalline powder  

Purity: ≥98% (HPLC/TLC)  

Ⅰ. Raw Material Introduction  

Spermidine trihydrochloride is the hydrochloride salt of a natural polyamine abundantly present in organisms (e.g., plants, microbes, and animal cells). Sourced via precision fermentation of GRAS yeast strains, it is purified to high purity (≥98%) through standardized processes. As a key regulator of cellular growth and proliferation, it plays central roles in maintaining DNA stability, protein function, and autophagy.  

Ⅱ. Key Characteristics  

1.High Purity & Stability:  

  ≥98% purity; retains activity under dry, low-temperature storage.  

  Soluble in water (50 mg/mL) and partially in DMSO.  

2.Multifunctional Bioactivities:  

  Autophagy Induction: Activates cellular autophagy to clear damaged components and delay aging.  

  Antioxidant & Anti-inflammatory: Suppresses ROS generation and reduces pro-inflammatory cytokines (e.g., TNF-α).  

  Neuro- & Cardio-Protection: Modulates NMDA receptors, enhances mitochondrial function, and promotes vasodilation.  

  DNA/Protein Binding: Forms stable complexes with nucleic acids and proteins for biomolecule purification.  

3.Safety Profile:  

  Clinical trials confirm no significant adverse effects with 40 mg/day supplementation for 28 days.  

Ⅲ. Product Applications  

1.Pharmaceutical R&D:  

  Neurodegenerative Disease Models: Protects neurons from oxidative stress in Alzheimer’s and Parkinson’s research.  

  Cancer Drug Development: Synergizes with chemotherapeutics (e.g., difluoromethylornithine) to induce apoptosis.  

  Osteoarthritis Management: Alleviates joint inflammation via NF-κB pathway inhibition.  

2.Functional Foods & Supplements:  

  Spermidine powder added to capsules/powders (10–40 mg/day) for anti-aging benefits.  

  Combines with B vitamins and botanicals for enhanced efficacy.  

3.Research Reagents:  

  Chromosome Isolation: Used in bivariate flow cytogenetic analysis.  

  Protein Purification: Isolates target proteins (e.g., Rad51) via selective precipitation.  

  Nucleic Acid Studies: Facilitates DNA digestion and histone protection.  

Ⅳ. Product Advantages  

1.Strong Scientific Backing:  

  Mechanisms well-documented in autophagy, antioxidant, and metabolic support.  

  Epidemiological studies link higher spermidine powder intake to reduced all-cause mortality.  

2.Advanced Manufacturing:  

  Supercritical CO₂ extraction and low-temperature crystallization ensure >95% active retention.  

  Solvent-free, compliant with pharmaceutical-grade standards.  

3.Formulation Flexibility:  

  Spermidine powder suitable for solids, liquids, and gels.  

  Customizable options (e.g., particle size, blends).  

Ⅴ. Company Strengths  

1.End-to-End Quality Control:  

  Full traceability from microbial fermentation to packaging, with third-party COA/HPLC certification.  

2.Regulatory Compliance:  

  Meets FDA GRAS, EU ECOCERT, and REACH requirements.  

3.R&D and Service Support:  

  Collaborations with research institutions and peer-reviewed publications.  

  Free samples, technical documents, and customized solutions available.  

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