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2024
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Can Urolithin A Help Improve Alzheimer's Disease?
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Recently,a statement has attracted great attention from the medical community.An international study in Vilnius,Xinhua News Agency,found that a metabolite of natural polyphenols contained in pomegranates,raspberries,walnuts,almonds and other nuts-urine.Lithin A can help improve the cognitive ability of experimental mice and has the potential to prevent and treat Alzheimer's disease.
Before understanding urolithin,let’s first understand mitochondria.
Mitochondria are the main site of cellular respiration.Mitophagy clears damaged or redundant mitochondria,and impairment of this function plays an important role in the development and progression of neurodegenerative diseases such as Alzheimer's disease.
Researchers from Denmark's University of Copenhagen and other research institutions recently discovered through mouse experiments that a natural compound,urolithin A,can stimulate mitophagy.Long-term feeding of this compound can improve the learning,memory and sense of smell of mice.The significant improvement in function is small,and the significant pathological characteristics of Alzheimer's disease such as abnormal deposition of beta amyloid protein and excessive phosphorylation of Tau protein are reduced.
Natural urolithin A is found in fruits such as pomegranates and raspberries as well as some nuts.The natural polyphenol compounds contained in these foods produce urolithin A after being metabolized by intestinal microorganisms.
However,the researchers say it's not yet clear how much of the substance is needed to improve memory and relieve Alzheimer's symptoms,so they don't recommend rushing to recommend urolithin A dietary supplements to Alzheimer's patients.
Lithuanian media quoted registered dietitian Melissa Prest as saying that the best way to get more urolithin A is to eat foods that can stimulate the production of urolithin A in the body,such as pomegranates,nuts,etc.The most important thing is to follow a healthy lifestyle-that is,get at least 7 hours of sleep every night and get adequate physical activity during the day.
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